Defining heavy metal requires we look at its many attributes as part of a whole. Heavy metal is is a musical style with certain compositional tenets without which. The Three Pillars of Heavy Metal Detoxification. By Dr. Mercola. Mercury is a pernicious neurotoxin. Removing it, however, needs to be done with great care, lest you cause even more problems. Chris Shade, Ph. D., is probably one of the foremost experts in the world on the subject of heavy metal detoxification, and in this interview, he shares his wisdom on this important topic. Shade received his Ph. D. from the University of Illinois Urbana Champaign where he studied the environmental transformations of mercury. Hes developed a patented liquid chromatographic mercury speciation technology that differentiates and identifies the exactly source of your mercury whether its from your dental amalgams, or from eating contaminated seafood. Heavy Metal 2000 Free Download' title='Heavy Metal 2000 Free Download' />Hes also involved in developing new lipid based delivery systems for nutraceuticals, including liposomes and micro emulsion systems to address the need for effective and affordable detoxification. We had sophisticated computational tools for telling us what kind of ligands binding molecules are holding the mercury. What I was tasked with was developing an analytical system for separating different forms of mercury out, he says. Youve got methylmercury which is the form that builds up in fish and then you have inorganic mercury. In the environment, inorganic mercury is everywhere. I developed these chromatographic tools that would enable a high throughput analysis of biological samples to separate these different forms. The Mercury Tri Test. In your body, glutathione is the dominant agent that binds to and helps move mercury and other heavy metals out of your tissues. Part of effectively eliminating mercury involves methods that help upregulate certain aspects of your chemistry that then mobilizes and moves the mercury out. I actually used Shades diagnostic tests and detox processes about five years ago to help me detox from mercury amalgams, and was able to cut my mercury level down to normal, quite quickly. How To Watch The Full Pokemon Heroes Movie more. The test he developed is called the Mercury Tri Test, because it looks at three different kinds of samples blood, hair, and urine. You always have more mercury in your tissues than in your blood. But theres a steady state or ratio between whats in your blood and whats in your tissues. Hair is an excretion marker for methylmercury, while urine is an excretion marker for inorganic mercury. These levels should be directly proportional to the levels in your blood. The most telling of these, the most importantly diagnostic of these ratios, is looking at the inorganic mercury in the blood compared to the inorganic mercury in the urine. For a given amount of inorganic mercury in the blood, there should be roughly a seven fold increase in the urine, as mercury is filtered out in the urine. But what we find that a lot of people have low mercury in urine, and high mercury in their blood. What the Blood to Urine Ratios Indicate. The reason for this has to do with retention toxicity. If two people have 1. More specifically, when the mercury in your blood rises above the 1 7 ratio to the urine, it means your proximal tubule transporters in your kidneys have been damaged. Your kidneys filter everything in your blood. Effect of heavy metal stress on antioxidative enzymes and lipid peroxidation in leaves and roots of two mangrove plant seedlings Kandelia candel and Bruguiera. Original Fantasy Rock Operas in Seattle, WA. Combines elements of experimental theater and symphonic operatic heavy metal to create a unique production that is. The three pillars of heavy metal detox are Cleanse and clear your GI tract of metals and toxins, optimize glutathione, and upregulate detox genes. After the general filtration, in the proximal tubules your body resorbs ions and nutrients it needs to keep, while toxins are actively shuttled out into the urine flow. This is what were measuring that movement into the urinary flow of the toxic conjugates. That area in the proximal tubules is very, very easily damaged. In mouse models, a combination of endotoxin and mercury exposure creates that damage to those transport proteins. Obviously, probably the biggest thing on the radar of integrative and functional medicine right now is leaky gut syndrome and gastrointestinal GI problems. They are the number one cause of getting high endotoxin levels in your body. If you have a high mercury level and a leaky gut, youre very likely to damage the very transport system thats getting that mercury out of your body. Thats going to lead to increased inorganic mercury levels in the blood. That diagnostic is really important. If that ratios off, we need to start by treating your kidneys before we go into the main detoxification. The Difference Between Inorganic Mercury and Methylmercury. The Mercury Tri Test is the only clinical test out there that differentiates between the inorganic form of mercury typically found in amalgam fillings and organic mercury or methylmercury from fish, allowing you to tailor the most ideal detoxification protocol for your situation. While many believe all mercury is the same, this is not necessarily the case. Inorganic mercury is much more toxic to the extracellular matrix and thus to connective tissues. If youre having joint problems or fibromyalgia like pain, you need to work on getting rid of this inorganic mercury, and you need to make sure your kidney transporters are working well. Metylmercury is a less cytotoxic toxic to the cells form of mercury. If you only have methylmercury in your body, its all going through glutathione conjugation to your liver, and on to your GI tract. On the cellular level, the inorganic mercury, is more disruptive because it can bind to more sulfhydryl groups and disrupt more chemistry than methylmercury can. For instance, if somebody only has methyl mercury exposure from eating fish and has no amalgams. But thats not a fixed rate. Thats an individual reaction that we dont really understand. I suspect its related to oxidative stress. But some people break down a lot and really build up this inorganic mercury pool despite not having amalgams some people breakdown only a little bit. Those who break down a lot are much more at risk from toxicity from their fish than if theyre not doing that. They have two forms of mercury building up in their blood, including the worst one the inorganic mercury. Its important that we divide those and see how well youre excreting the two. Primary Sources of Mercury Exposure. Seafood is essentially the sole source of methylmercury. However, its a major source of mercury, and it can be problematic if you eat a lot of seafood. The type of seafood you eat also plays a big role. At the top of the food chain, a shark might have 4 parts per million ppm to 1. According to Shade, swordfish is routinely 1 to 5 ppm, and tuna is routinely in the 1 to 2 ppm range. Toward the bottom of the food chain you have sardines and anchovies, which may contain 1 to 1. Wild salmon like Coho and sockeye can be in the 1. Depending on the fish you compare, there could be a thousand fold difference between the mercury levels. To put that into perspective, its like eating 1,0. So if you eat fish on a regular basis, its really important to look for species known to be low in mercury. A dentist I know, Dr. Dave Regiani, had mercury levels measured with us. I said, You obviously dont eat any fish. He goes, I eat fish every day. So I said, Sardines and anchovies He said, You got it. It looks like hes not eating fish at all. When you get down into kippers, anchovies, and sardines, you can eat them at will all day long, and youre never going to build up high levels of mercury. Inorganic mercury exposure is dominantly from dental amalgam and the breakdown of fish based mercury into the inorganic form. Airborne mercury is the third and least troublesome source. Exceptions include some older buildings, such as old medical, dental, agricultural, and scientific buildings, where mercury levels could be quite significant. How Mercury Damages Your Health. Inorganic mercury and cadmium are the two heavy metals that cause the most damage to your kidneys. They tend to build up there, causing a downward spiral where the more damage there is to the proximal tubules, the more metals accumulate, and the more damage is created. Many have suffered damage from doing chelation for this reason.